The role of BRAF mutation in patients with high-risk malignant melanoma treated with high-dose adjuvant interferon therapy
作者: Tulay AkmanIlhan OztopYasemin BaskinMahdi AkbarpourOlcun Umit UnalUtku OflazogluHulya Ellidokuz
作者单位: 1Department of Medical Oncology, Tepecik Training and Research Hospital
2Department of Medical Oncology, Dokuz Eylul University Faculty of Medicine
3Department of Basic Oncology, Institute of Oncology, Dokuz Eylul University
4Department of Medical Oncology, Ataturk University
5Department of Preventive Oncology, Institute of Oncology, Dokuz Eylul University
刊名: Medical Oncology, 2015, Vol.32 (1), pp.1-10
来源数据库: Springer Nature Journal
DOI: 10.1007/s12032-014-0440-7
关键词: BRAFAdjuvant high-dose interferonSurvivalClinicopathological features
英文摘要: Abstract(#br)Data regarding the prognostic importance of BRAFV600 tumor mutations in high-risk, non-metastatic, stage 2 and 3 malignant melanoma (MM) patients are controversial. There is not sufficient information in the medical literature regarding the reliability of BRAF mutations as a predictive factor in prognosis and adjuvant treatment decision issues in this patient group. The data of 50 operated high-risk, non-metastatic, stage 2B/2C and 3 MM patients who received high-dose interferon alfa-2b therapy were evaluated retrospectively. BRAF mutations were analyzed by using microarray-based molecular methods. The associations between BRAF mutations and both clinicopathological characteristics and survival were assessed. Of the 50 patients, 52 % was female and 48 % was male, and the...
全文获取路径: Springer Nature  (合作)
影响因子:2.147 (2012)

  • interferon 干扰素
  • adjuvant 辅助剂
  • melanoma 黑瘤
  • treated 加工的
  • malignant 恶性的
  • mutation 变种
  • therapy 治疗