Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk
作者: Daniele CampaJames McKayOlga SinilnikovaAnika HüsingUlla VogelRikke Dalgaard HansenKim OvervadPetra Mariann WittFrançoise Clavel-ChapelonMarie-Christine Boutron-RuaultVeronique ChajesSabine RohrmannJenny Chang-ClaudeHeiner BoeingEva FisherAntonia TrichopoulouDimitrios TrichopoulosDomenico PalliAnna VillariniCarlotta SacerdoteAmalia MattielloRosario TuminoPetra H. M. PeetersCarla H. GilsH. Bas Bueno-de-MesquitaEiliv LundMaría Dolores ChirlaqueNúria Sala
作者单位: 1Department of Cancer Epidemiology, German Cancer Research Center (DKFZ)
2University of Pisa
3International Agency for Research on Cancer
4Hospices Civils de Lyon/Centre Léon Bérard, CNRS-Université Claude Bernard UMR5201
5National Food Institute, Technical University of Denmark
6Danish Cancer Society
7Aarhus University Hospital
8Insitut Gustave Roussy
9German Institute of Human Nutrition
10Department of Hygiene and Epidemiology, Medical School, University of Athens
11Department of Epidemiology, Havard School of Public Health
12Cancer Research and Prevention Institute (ISPO)
13Istituto Nazionale dei Tumori (IRCCS)
14CPO Piemonte
15Federico II University
16Azienda Ospedaliera “Civile M.P. Arezzo”
17Julius Center, University Medical Center
18National Institute for Public Health and the Environment
19Institute of Community Medicine University of Tromsø
20Murcia Health Council
21Catalan Institute of Oncology
22Consejería de Salud y Servicios Sanitarios Principado de Asturias
23Public Health Institute of Navarra
24Public Health Department of Gipuzkoa and CIBER de Epidemiología y Salud Pública (CIBERESP)
25Andalusian School of Public Health and CIBERESP
26Umeå University
27University of Oxford
28University of Cambridge
29Imperial College
刊名: Breast Cancer Research and Treatment, 2009, Vol.118 (3), pp.565-574
来源数据库: Springer Journal
DOI: 10.1007/s10549-009-0347-8
关键词: Fatty acid synthaseCarbohydrate response element-binding proteinSterol response element-binding protein-1Breast cancerSusceptibility to cancerBody-mass index
英文摘要: Abstract(#br)Fatty acid synthase (FAS) is the major enzyme of lipogenesis. It catalyzes the NADPH-dependent condensation of acetyl-CoA and malonyl-CoA to produce palmitic acid. Transcription of the FAS gene is controlled synergistically by the transcription factors ChREBP (carbohydrate response element-binding protein), which is induced by glucose, and SREBP-1 (sterol response element-binding protein-1), which is stimulated by insulin through the PI3K/Akt signal transduction pathway. We investigated whether the genetic variability of the genes encoding for ChREBP, SREBP and FAS (respectively, MLXIPL , SREBF1 and FASN ) is related to breast cancer risk and body-mass index (BMI) by studying 1,294 breast cancer cases and 2,452 controls from the European Prospective Investigation on Cancer...
全文获取路径: Springer  (合作)
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影响因子:4.469 (2012)

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关键词翻译
关键词翻译
  • variation 变异
  • synthesis 合成
  • fatty 脂肪的
  • breast 胸部
  • cancer 癌症
  • pathway 轨道