Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation
作者: Dadong GuoChunhui WuJingyuan LiAirong GuoQingning LiHui JiangBaoan ChenXuemei Wang
作者单位: 1State Key Lab of Bioelectronics (Chien-Shiung Wu Lab), Southeast University
2Zhongda Hospital, School of Clinical Medical, Southeast University
刊名: Nanoscale Research Letters, 2009, Vol.4 (12), pp.1395-1402
来源数据库: Springer Journal
DOI: 10.1007/s11671-009-9411-x
关键词: Nickel nanoparticlesReal-time cell electronic sensing (RT-CES) studyMTT assayElectrochemical analysisHepatocellular carcinoma cell line
英文摘要: Abstract(#br)The effect of functionalized nickel (Ni) nanoparticles capped with positively charged tetraheptylammonium on cellular uptake of drug quercetin into hepatocellular carcinoma cells (SMMC-7721) has been explored in this study via microscopy and electrochemical characterization as well as MTT assay. Meanwhile, the influence of Ni nanoparticles and/or quercetin on cell proliferation has been further evaluated by the real-time cell electronic sensing (RT-CES) study. Our observations indicate that Ni nanoparticles could efficiently improve the permeability of cancer cell membrane, and remarkably enhance the accumulation of quercetin in SMMC-7721 cells, suggesting that Ni nanoparticles and quercetin would facilitate the synergistic effect on inhibiting proliferation of cancer cells.
全文获取路径: Springer  (合作)
影响因子:2.524 (2012)