PLA2R antibodies and PLA2R glomerular deposits in psoriasis patients with membranous nephropathy
作者: Yong-Chun GeBo JinCai-Hong ZengMing-Chao ZhangDa-Cheng ChenRu YinWei-Bo Le
作者单位: 1Nanjing University School of Medicine
刊名: BMC Nephrology, 2016, Vol.17 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12882-016-0407-3
关键词: Membranous nephropathyPsoriasisPLA2RRenal biopsyTHSD7A
原始语种摘要: Abstract(#br) Background(#br)The association between psoriasis and membranous nephropathy (MN) remains largely unclear. We examined the prevalence of serum PLA2R antibody and characterized the expression of PLA2R and THSD7A in glomeruli in patients with MN and psoriasis.(#br) Methods(#br)A total of 24 patients with MN without evidence of a secondary cause except psoriasis were enrolled. The clinical and pathological features were retrospectively analyzed. Serum anti-PLA2R antibody was measured using IFA Mosaic. Renal tissue samples stored in the laboratory bio-bank were used for PLA2R staining under immunofluorescence microscopy and THSD7A immunohistochemical analysis.(#br) Results(#br)Twenty-four patients (21 male and 3 female) with a mean age of 43.6 ± 15.7 years old were enrolled....
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影响因子:1.644 (2012)

  • nephropathy 肾病
  • glomerular 肾小球病
  • psoriasis 干癣
  • membranous 薄膜状的
  • PLA phase alternating line