Effect of Age and Sex on Lacosamide Pharmacokinetics in Healthy Adult Subjects and Adults with Focal Epilepsy
作者: Carina SchaeferWilli CawelloJosef WaitzingerJan-Peer Elshoff
作者单位: 1UCB Pharma
2Institute of Clinical Pharmacy and Pharmacotherapy, University of Düsseldorf
刊名: Clinical Drug Investigation, 2015, Vol.35 (4), pp.255-265
来源数据库: Springer Journal
DOI: 10.1007/s40261-015-0277-7
英文摘要: Abstract(#br) Background and Objective(#br)Age- and sex-related differences in body composition could affect the pharmacokinetic parameters of administered drugs. The purpose of this post hoc analysis was to investigate the influences of age and sex on the pharmacokinetics of lacosamide.(#br) Methods(#br)This post hoc analysis used pharmacokinetic data taken at steady state from (i) two phase I studies of oral lacosamide in healthy adult subjects ( n = 66), and (ii) a population pharmacokinetic analysis carried out using data from two phase III studies of adjunctive oral lacosamide in adults ( n = 565) with focal epilepsy taking 1–3 concomitant anti-epileptic drugs. Phase I data were stratified by age and sex as ‘younger female’ (aged 18–40 years), ‘younger male’ (aged 18–45 years) or...
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影响因子:1.915 (2012)