Simulating recurrent event data with hazard functions defined on a total time scale
作者: Antje Jahn-EimermacherKatharina IngelAnn-Kathrin OzgaStella PreusslerHarald Binder
作者单位: 1University Medical Center Johannes Gutenberg University Mainz
刊名: BMC Medical Research Methodology, 2015, Vol.15 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12874-015-0005-2
关键词: Andersen-GillRecurrent eventsRecurrent failure timesSimulationTotal timeCalendar time
原始语种摘要: Abstract(#br) Background(#br)In medical studies with recurrent event data a total time scale perspective is often needed to adequately reflect disease mechanisms. This means that the hazard process is defined on the time since some starting point, e.g. the beginning of some disease, in contrast to a gap time scale where the hazard process restarts after each event. While techniques such as the Andersen-Gill model have been developed for analyzing data from a total time perspective, techniques for the simulation of such data, e.g. for sample size planning, have not been investigated so far.(#br) Methods(#br)We have derived a simulation algorithm covering the Andersen-Gill model that can be used for sample size planning in clinical trials as well as the investigation of modeling techniques....
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影响因子:2.211 (2012)

  • event 事件
  • scale 度盘
  • hazard 危险
  • total 总和
  • defined 定义
  • recurrent 循环的