Fucoxanthin Enhances Chain Elongation and Desaturation of Alpha-Linolenic Acid in HepG2 Cells
作者: Meng-Ting WuHui-Min SuYi CuiAnthony WindustHong-Nong ChouChing-jang Huang
作者单位: 1National Taiwan University
2National Research Council
刊名: Lipids, 2015, Vol.50 (10), pp.945-953
来源数据库: Springer Journal
DOI: 10.1007/s11745-015-4059-z
关键词: FucoxanthinDelta-5 desaturaseElongationALAEPADHAn-3 PUFA
英文摘要: Abstract(#br)Dietary fucoxanthin (FX), a carotenoid compound from brown algae, was found to increase docosahexaenoic acid (DHA, 22:6n-3) and arachidonic acid (ARA, 20:4n-6) in the liver of mice. DHA and ARA are known to be biosynthesized from the respective precursor α-linolenic acid (ALA, 18:3n-3) and linoleic acid (LNA, 18:2n-6), through desaturation and chain elongation. We examined the effect of FX on the fatty acid metabolism in HepG2 cells (Hepatocellular carcinoma, human). In the first experiment, cells were co-treated with ALA (100 μM) and FX (0–100 μM) or vehicle for 48 h. FX increased eicosapentaenoic acid (EPA, 20:5n-3), docosapentaenoic acid (DPA, 22:5n-3), DHA at concentrations of ≥50 μM. To clarify the change in the metabolism of polyunsaturated fatty acid (PUFA), in the...
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影响因子:2.557 (2012)

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