The role of cancer-associated fibroblasts in esophageal cancer
作者: Jiangfeng WangGuangyu ZhangJianbo WangLu WangXiaochen HuangYufeng Cheng
作者单位: 1Qilu Hospital of Shandong University
刊名: Journal of Translational Medicine, 2016, Vol.14 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12967-016-0788-x
关键词: Esophageal cancerCancer-associated fibroblastsCarcinogenesisProgressionMetastasisPrognosisTreatment
英文摘要: Abstract(#br)Fibroblasts are known as critical stromal cells in wound healing by synthesizing extracellular matrix and collagen. A subpopulation of them is called cancer-associated fibroblasts (CAFs), because their production of proteins participated in various biological activities including tumor cell proliferation, invasion and metastasis. Currently some studies shed light on their role in esophageal cancer which was an aggressive cancer with a dismal survival and high rate of metastasis. Thus, to find cures for it relies on elucidating the epithelial-fibroblasts crosstalk. Herein, we reviewed the present knowledge of the CAFs’ role in esophageal premalignant condition, cancer initiation, progression, metastasis and prognosis prediction and further provided some insights into its...
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影响因子:3.459 (2012)

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关键词翻译
关键词翻译
  • esophageal 食管的
  • associated 相关的
  • cancer 癌症