Expressions of VEGF-A and VEGFR-2 in placentae from GDM pregnancies
作者: Qian MengLi ShaoXiucui LuoYingping MuWen XuLi GaoHaoqin XuYugui Cui
作者单位: 1Lianyungang Maternity and Child Health Care Hospital
2Center of Clinical Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University
3Jiangsu Institute of Planned Parenthood Research
刊名: Reproductive Biology and Endocrinology, 2016, Vol.14 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12958-016-0191-8
关键词: GDMPlacentaVascular endothelial growth factorReceptorsFetal development
英文摘要: Abstract(#br) Background(#br)Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy, and has important health implications for mother and child. Changes in the fetoplacental vessels may predict those in the vasculature of the developing fetus, as these have been implicated in the pathogenesis of human GDM. This study aimed to determine the differences in the localization and expression level of VEGFA and VEGFR2 between placentas of women with GDM and placentas of normal pregnancies, which is the first step in elucidating the possible roles of VEGFA and VEGFR2 in the altered uteroplacental function resulting from maternal hyperglycaemia and ultimately in the manifestation of GDM.(#br) Methods(#br)The expressions of VEGFA and VEGFR2 mRNA and protein...
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影响因子:2.144 (2012)

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