Radiosensitization with combined use of olaparib and PI-103 in triple-negative breast cancer
作者: Na Young JangDan Hyo KimBong Jun ChoEun Jung ChoiJong-Soo LeeHong-Gyun WuEui Kyu ChieIn Ah Kim
作者单位: 1Graduate School of Medicine, Seoul National University
2Veterans Health Service Medical Center
3Seoul National University Bundang Hospital
4College of Natural Sciences, Ajou University
5Seoul National University
6Cancer Research Institute, Seoul National University
刊名: BMC Cancer, 2015, Vol.15 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12885-015-1090-7
关键词: Triple-negative breast cancerRadiotherapyOlaparibPI-103PARP inhibitorPI3K inhibitor
英文摘要: Abstract(#br) Background(#br)Triple-negative breast cancer (TNBC) shows aggressive clinical behavior, but the treatment options are limited due to lack of a specific target. TNBC shares many clinical and pathological similarities with BRCA-deficient breast cancer, for which poly(ADP-ribose) polymerase (PARP) inhibitor is effective, but PARP inhibitor alone failed to show clinical effects in patients with sporadic TNBC. Radiation induces DNA double-strand breaks, and the phosphoinositide 3-kinase (PI3K) signaling pathway has been known to regulate steady-state levels of homologous recombination. A recent preclinical study showed that PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient TNBC to PARP inhibition. Therefore, we assessed the radiosensitizing effect, and the...
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影响因子:3.333 (2012)

  • combined 组合
  • breast 胸部
  • triple 三重的
  • cancer 癌症
  • negative 负象