CLIP-GENE: a web service of the condition specific context-laid integrative analysis for gene prioritization in mouse TF knockout experiments
作者: Benjamin HurSangsoo LimHeejoon ChaeSeokjun SeoSunwon LeeJaewoo KangSun Kim
作者单位: 1Seoul National University
2Indiana University
3Korea University
刊名: Biology Direct, 2016, Vol.11 (1)
来源数据库: Springer Journal
DOI: 10.1186/s13062-016-0158-x
关键词: Knockout mouseGene prioritizationGene selectionWeb tool
英文摘要: Abstract(#br) Motivation(#br)Transcriptome data from the gene knockout experiment in mouse is widely used to investigate functions of genes and relationship to phenotypes. When a gene is knocked out, it is important to identify which genes are affected by the knockout gene. Existing methods, including differentially expressed gene (DEG) methods, can be used for the analysis. However, existing methods require cutoff values to select candidate genes, which can produce either too many false positives or false negatives. This hurdle can be addressed either by improving the accuracy of gene selection or by providing a method to rank candidate genes effectively, or both. Prioritization of candidate genes should consider the goals or context of the knockout experiment. As of now, there are no...
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影响因子:2.72 (2012)

  • knockout 出模器
  • mouse 小鼠
  • integrative 综合
  • condition 条件
  • specific 
  • analysis 分析
  • service 服务
  • prioritization 优先化
  • context 菌髓
  • web 梁腹板