Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population
作者: Wen-Yi YangThibault PetitLutgarde ThijsZhen-Yu ZhangLotte JacobsAzusa HaraFang-Fei WeiErika SalviLorena CitterioSimona Delli CarpiniYu-Mei GuJudita KnezNicholas CauwenberghsMatteo BarcellaCristina BarlassinaPaolo ManuntaGiulia CoppielloXabier L. ArangurenTatiana KuznetsovaDaniele CusiPeter VerhammeAernout LuttunJan A. Staessen
作者单位: 1University of Leuven
2University of Milan
3University Vita-Salute San Raffaele
4Maastricht University
刊名: BMC Genetics, 2015, Vol.16 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12863-015-0272-2
关键词: Clinical geneticsCoronary heart diseaseMEOX2Population scienceTCF15Translational research
原始语种摘要: Abstract(#br) Background(#br)In mice MEOX2/TCF15 heterodimers are highly expressed in heart endothelial cells and are involved in the transcriptional regulation of lipid transport. In a general population, we investigated whether genetic variation in these genes predicted coronary heart disease (CHD).(#br) Results(#br)In 2027 participants randomly recruited from a Flemish population (51.0 % women; mean age 43.6 years), we genotyped six SNPs in MEOX2 and four in TCF15 . Over 15.2 years (median), CHD, myocardial infarction, coronary revascularisation and ischaemic cardiomyopathy occurred in 106, 53, 78 and 22 participants. For SNPs, we contrasted CHD risk in minor-allele heterozygotes and homozygotes (variant) vs. major-allele homozygotes (reference) and for haplotypes carriers (variant)...
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影响因子:2.808 (2012)

  • Flemish 佛兰芒人
  • variation 变异
  • relation 关系
  • population 母体
  • genetic 遗传的
  • TCF Trim Centering and Feel