Does sildenafil have protective effects against ovarian ischemia-reperfusion injury in rats?
作者: Adnan IncebiyikAhmet SekerHakan CamuzcuogluSezen KocaslanAysun CamuzcuogluNese Gul HilaliMehmet VuralAbdullah TaskinNurten Aksoy
作者单位: 1Harran University School of Medicine
2Harran University
3Marmara University
刊名: Archives of Gynecology and Obstetrics, 2015, Vol.291 (6), pp.1283-1288
来源数据库: Springer Nature Journal
DOI: 10.1007/s00404-014-3554-4
关键词: Adnexal torsionIschemia-reperfusion injurySildenafilRat model
英文摘要: Abstract(#br) Purpose(#br)The aim of this study was to evaluate the protective activity of sildenafil treatment against ischemia-reperfusion damage created experimentally in rat ovaries.(#br) Methods(#br)For this study, 42 female Wistar rats were used, and the rats were separated randomly into six groups consisting of seven rats each: sham, torsion, torsion-detorsion, torsion-detorsion + saline, torsion-detorsion + sildenafil 0.7 mg/kg and torsion-detorsion + sildenafil 1.4 mg/kg. With the exception of the sham group, an ovarian torsion procedure was implemented in all other groups for 2 h. Then, a detorsion procedure was implemented to the groups for 2 h, with the exception of the torsion group. Medications were given intraperitoneally, one-half hour before the detorsion procedure in the...
全文获取路径: PDF下载  Springer Nature  (合作)
影响因子:1.33 (2012)

  • against 反对
  • ovarian 卵巢的
  • reperfusion 多次灌注液
  • ischemia 局部贫血
  • injury 损害
  • protective 保护的
  • effects 海员自身物品