Heterogeneity of ERG expression in prostate cancer: a large section mapping study of entire prostatectomy specimens from 125 patients
作者: Maria-Christina TsourlakisAnnegret StenderAlexander QuaasMartina KluthCorinna WittmerAlexander HaeseMarkus GraefenStefan SteurerRonald SimonJan KorbelJoachim WeischenfeldtHartwig HulandGuido SauterThorsten SchlommSarah Minner
作者单位: 1University Medical Center Hamburg-Eppendorf
2Genome Biology Unit, European Molecular Biology Laboratory (EMBL)
刊名: BMC Cancer, 2016, Vol.16 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12885-016-2674-6
关键词: Prostate cancerERGHeterogeneity
英文摘要: Abstract(#br) Background(#br)TMPRSS2:ERG fusions are frequent in prostate cancer, and occur predominantly in young patients. Several studies had proposed intratumoral heterogeneity of these fusions. This study was designed to determine frequency and extent of ERG fusion heterogeneity in early-onset prostate cancer (EO-PCA, <50 years) and in elderly patients.(#br) Methods(#br)The prostates from 63 EO-PCA and 62 elderly prostate cancer patients were thoroughly reviewed for presence of cancer foci. All 1592 tumor-containing sections were analyzed by immunohistochemistry for ERG expression.(#br) Results(#br)The prostates included in this study contained one tumor focus in 44, two tumor foci in 21, three tumor foci in 32, four tumor foci in 15, and five or more tumor foci in 13 patients. Among...
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影响因子:3.333 (2012)

  • prostatectomy 前列腺切除术
  • ERG 视网膜电图
  • expression 表示
  • large 大的
  • entire 完整的
  • section 薄片
  • mapping 映象
  • cancer 癌症
  • study 学习