Functional characterization of Mammary Gland Protein-40, a chitinase-like glycoprotein expressed during mammary gland apoptosis
作者: Vijay AnandShalini JaswalSurender SinghSudarshan KumarManoj Kumar JenaArvind Kumar VermaMunna Lal YadavJagadeesh JanjanamMasoud LotfanDhruba MalakarAjay Kumar DangTushar Kumar MohantyJai Kumar KaushikAshok Kumar Mohanty
作者单位: 1National Dairy Research Institute (NDRI)
2University of Tennessee Health Science Center
刊名: Apoptosis, 2016, Vol.21 (2), pp.209-224
来源数据库: Springer Journal
DOI: 10.1007/s10495-015-1196-z
关键词: Buffalo Mammary Epithelial cellsCytoprotectionProlactinStat3Epithelial Mesenchymal Transition
英文摘要: Abstract(#br)MGP-40 is a chitinase-like protein which is over expressed during mammary gland involution. However, its physiological function in the mammary gland is poorly understood. In the present investigation, we have reported the functional significance of buffalo specific MGP-40 in the mammary gland by using an in vitro model of the buffalo mammary epithelial cell (BuMEC) line. MGP-40 was highly up regulated in BuMECs in serum starved condition as well as after treatment with prolactin suggesting its role in the stress response. Subsequently, to study the effect of MGP-40 on BuMECs, the cells were transfected with a mammalian expression construct of pCI neo harboring MGP-40 gene. It was observed that over expression of MGP-40 enhanced proliferation of BuMECs and protected the cells...
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影响因子:3.949 (2012)

  • expressed 榨出的
  • chitinase 壳质酶
  • glycoprotein 糖蛋白
  • mammary 乳房的
  • gland 
  • during 在的期间
  • apoptosis 细胞死