Periosteal cells are a major source of soft callus in bone fracture
作者: Hiroki MuraoKoji YamamotoShuichi MatsudaHaruhiko Akiyama
作者单位: 1Department of Orthopaedics, Kyoto University
刊名: Journal of Bone and Mineral Metabolism, 2013, Vol.31 (4), pp.390-398
来源数据库: Springer Nature Journal
DOI: 10.1007/s00774-013-0429-x
关键词: Fracture healingPeriosteal cellsSoft callusCell lineageSox9
英文摘要: Abstract(#br)During the healing process after bone fracture, soft callus forms adjacent to the fracture site, is replaced by hard callus, and is finally remodeled to the original bone configuration. Although the cambium layer of the periosteum is reported to play an essential role in callus formation, we still lack direct in vivo evidence of this. To investigate the cell lineage of the soft callus, we analyzed the process of fracture healing in Prx1 - Cre;ROSA26 reporter ( R26R ), Col1a1(3.6 kb) - Cre;R26R , Col1a1(2.3 kb) - Cre;R26R , Sox9 - CreERT2;R26R , and Sox9 - LacZ mice with X-gal staining. In the Prx1 - Cre;R26R , in which the cells of the periosteum stained for X-gal before fracture, all cells in the soft callus were X-gal positive, whereas in the Col1a1(3.6 kb) - Cre;R26R mice,...
全文获取路径: Springer Nature  (合作)
影响因子:2.219 (2012)

  • callus 骨痂
  • cells 麻风细胞
  • fracture 断口
  • major 知的
  • source