QoRTs: a comprehensive toolset for quality control and data processing of RNA-Seq experiments
作者: Stephen W. HartleyJames C. Mullikin
作者单位: 1National Human Genome Research Institute, National Institutes of Health
刊名: BMC Bioinformatics, 2015, Vol.16 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12859-015-0670-5
关键词: Quality ControlRNA-SeqNext-generation sequencingDifferential expressionDifferential transcript regulationDifferential splicing
英文摘要: Abstract(#br) Background(#br)High-throughput next-generation RNA sequencing has matured into a viable and powerful method for detecting variations in transcript expression and regulation. Proactive quality control is of critical importance as unanticipated biases, artifacts, or errors can potentially drive false associations and lead to flawed results.(#br) Results(#br)We have developed the Quality of RNA-Seq Toolset, or QoRTs, a comprehensive, multifunction toolset that assists in quality control and data processing of high-throughput RNA sequencing data.(#br) Conclusions(#br)QoRTs generates an unmatched variety of quality control metrics, and can provide cross-comparisons of replicates contrasted by batch, biological sample, or experimental condition, revealing any outliers and/or...
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来源刊物:
影响因子:3.024 (2012)

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关键词翻译
关键词翻译
  • control 控制
  • quality 品质
  • comprehensive 全面
  • processing 加工
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