Childhood myelodysplastic syndromes: Clinical features, cytogenetics and prognosis
作者: R. NairU. A. AthaleR. S. IyerC. N. NairS. K. PaiP. A. KurkureP. R. KadamS. H. Advani
作者单位: 1Department of Medical Oncology, Tata Memorial Hospital
刊名: The Indian Journal of Pediatrics, 1992, Vol.59 (4), pp.443-448
来源数据库: Springer Journal
DOI: 10.1007/BF02751559
关键词: Bone marrow transplantationChemotherapyKaryotypeLeukemic transformation
英文摘要: Abstract(#br)Sixteen children with myelodysplastic syndrome as defined by the French-American-British co-operative group are presented. The mean age was 10.5 (2.5 to 16) years, with a male predominence. All patients belonged to the more aggressive subtypes of myelodysplastic syndromes. Seven patients presented with refractory anaemia with excess blasts, six had refractory anemia with excess blasts in transformation, and three had chronic myelomonocytic leukemia. Cytogenetic analysis done in 7 of the 16 patients, revealed karyotype abnormalities involving chromosomes 7, 8 and 17. One patient with Down's syndrome had karyotype of 47, XY, +21 (major clone) and 46, XY (minor clone). Five of these patients evolved to acute leukemia. The mean duration of survival was 5.5 months. Aggressive...
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影响因子:0.715 (2012)

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关键词翻译
关键词翻译
  • prognosis 预报
  • cytogenetics 细胞遗传学
  • features 特征