Epstein–Barr virus association in classical Hodgkin's disease provides survival advantage to patients and correlates with higher expression of proliferation markers in Reed–Sternberg cells
作者: K. N. NareshJ. JohnsonV. SrinivasC. S. SomanT. SaikiaS. H. AdvaniR. A. BadweK. A. DinshawM. MuckadenI. MagrathK. Bhatia
作者单位: 1Department of Pathology, Tata Memorial Hospital
2Lymphoma Biology Section, National Cancer Institute
3Department of Radiation Oncology, Tata Memorial Hospital
4Clinical Research Secretariat, Tata Memorial Hospital
5Department of Medical Oncology, Tata Memorial Hospital
刊名: Annals of Oncology, 2000, Vol.11 (1), pp.91-96
来源数据库: Springer Journal
DOI: 10.1023/A:1008337100424
关键词: Epstein–Barr virusHodgkin's diseaseproliferationReed–Sternberg cell
英文摘要: Abstract(#br) Background: Most Epstein–Barr virus (EBV) associatedlymphoproliferative disorders have high proliferation indices. However,classical Hodgkin's disease (cHD) is heterogeneous, with respect toproliferation index of the Reed–Sternberg cell (RS cell), and EBVassociation. Hence, we investigated whether cHD with and withoutEBV-association differ with respect to the proliferation index of the RScells. Further we investigated whether this would have a bearing on patientssurvival.(#br) Patients and methods: We investigated 110 cases of cHD for: a) EBVassociation by immunohistochemical demonstration of EBV-latent membraneprotein-1 and EBV encoded nuclear RNA 1 by mRNA in situ hybridisation; b) Proliferating cell nuclear antigen (PCNA) expressionin the RS cells.(#br) Results: EBV...
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影响因子:7.384 (2012)

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关键词翻译
关键词翻译
  • survival 生存
  • markers 时标
  • association 联合
  • classical 经典的
  • cells 麻风细胞
  • advantage 利益
  • expression 表示
  • proliferation 增生
  • virus 病毒
  • higher