Prophylactic mastectomy in familial breast carcinoma. What do the pathologic findings learn us?
作者: Karin LeunenMaria DrijkoningenPatrick NevenMaria-Rose ChristiaensChantal OngevalEric LegiusFrédéric AmantPatrick BertelootIgnace Vergote
作者单位: 1Department of Obstetrics and Gynaecology, Division of Gynaecologic Oncology, Multidisciplinary Breast Centre, University Hospitals Leuven
2Department of Surgery, Multidisciplinary Breast Centre, University Hospitals Leuven
3Department of Radiology, Multidisciplinary Breast Centre, University Hospitals Leuven
4Department of Human Genetics, Catholic University Leuven
5Department of Pathology, Multidisciplinary Breast Centre, University Hospitals Leuven
刊名: Breast Cancer Research and Treatment, 2008, Vol.107 (1), pp.79-86
来源数据库: Springer Nature Journal
DOI: 10.1007/s10549-007-9525-8
关键词: Prophylactic mastectomyPathologic findingsBRCABreast-ovarian cancer families
英文摘要: Abstract(#br) Objective To evaluate the indications, techniques and pathologic findings of prophylactic mastectomy (pME). Methods Retrospective study of patients with a strong family history of breast cancer (and ovarian cancer) or with proven BRCA mutation. Results Between January 1995 and December 2005, sixty seven patients underwent pME: 15% had a BRCA1 mutation, 31% had a BRCA2 mutation and 33% had a strong family history but without proven BRCA mutation and in 21% mutation analysis was not performed. Fifty eight percent had a personal history of breast cancer of which 84% previously underwent a unilateral mastectomy as part of their treatment. The median time to decision from previous treatment for breast carcinoma to pME was 46 months. Mean age at pME was 43 years. Pathologic...
全文获取路径: Springer Nature  (合作)
影响因子:4.469 (2012)

  • mastectomy 乳房切除
  • breast 胸部
  • findings 结论
  • carcinoma 癌症
  • pathologic 病理学
  • familial 家族性
  • learn 学习