Intracellular pH regulatory mechanism in human atrial myocardium: Functional evidence for Na + /H + exchanger and Na + /HCO 3 − symporter
作者: Shih-Hurng LohWei-Hwa ChenCheng-Hsien ChiangChien-Sung TsaiGuo-Chen LeeJong-Shiaw JinTzu-Hurng ChengJin-Jer Chen
作者单位: 1Department of Gynecology, National Defense Medical Center
2Department of Cardiovascular Surgery, National Defense Medical Center
3Department of Pathology, National Defense Medical Center
4Institute of Biomedical Sciences, Academia Sinica
5Department of Pharmacology, National Defense Medical Center
刊名: Journal of Biomedical Science, 2002, Vol.9 (3), pp.198-205
来源数据库: Springer Nature Journal
DOI: 10.1007/BF02256066
关键词: Intracellular pHBCECF fluorescenceNa + -H + exchangerNa + -HCO 3 − symporterAcid extruderHuman atrium
英文摘要: Abstract(#br)Intracellular pH (pH i ) exerts considerable influence on cardiac contractility and rhythm. Over the last few years, extensive progress has been made in understanding the system that controls pH i in animal cardiomyocytes. In addition to the housekeeping Na + -H + exchanger (NHE), the Na + -HCO 3 − symporter (NHS) has been demonstrated in animal cardiomyocytes as another and extruder. However, whether the NHE and NHS functions exist in human atrial cardiomyocytes remains unclear. We therefore investigated the mechanism of pH i recovery from intracellular acidosis (induced by NH 4 Cl prepulse) using intracellular 2′,7′-bis(2-carboxethyl)-5(6)-carboxyfluorescein fluorescence in human atrial myocardium. In HEPES (nominally HCO 3 − -free) Tyrode solution, pH i recovery from...
全文获取路径: Springer Nature  (合作)
影响因子:2.458 (2012)

  • myocardium 心肌
  • symporter 同向转运
  • atrial 围鳃的
  • regulatory 控制的
  • evidence 
  • exchanger 交换器
  • mechanism 机构
  • human 人的