Application of a mathematical model and Differential Evolution algorithm approach to optimization of bacteriocin production by Lactococcus lactis C7
作者: Sompop MoonchaiWeeranuch MadlhooKanidtha JariyachavalitHiroshi ShimizuSuteaki ShioyaSomchai Chauvatcharin
作者单位: 1Department of Mathematics, Faculty of Science, Mahidol University
2Department of Biotechnology, Faculty of Science, Mahidol University
3Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University
4Department of Biotechnology, Graduate School of Engineering, Osaka University
刊名: Bioprocess and Biosystems Engineering, 2005, Vol.28 (1), pp.15-26
来源数据库: Springer Journal
DOI: 10.1007/s00449-005-0004-5
关键词: BacteriocinDifferential EvolutionLactococcus lactisTemperature profile
英文摘要: Abstract(#br)The effect of pH and temperature on cell growth and bacteriocin production in Lactococcus lactis C7 was investigated in order to optimize the production of bacteriocin. The study showed that the bacteriocin production was growth-associated, but declined after reaching the maximum titer. The decrease of bacteriocin was caused by a cell-bound protease. Maximum bacteriocin titer was obtained at pH 5.5 and at 22°C. In order to obtain a global optimized solution for production of bacteriocin, the optimal temperature for bacteriocin production was further studied. Mathematical models were developed for cell growth, substrate consumption, lactic acid production and bacteriocin production. A Differential Evolution algorithm was used both to estimate the model parameters from the...
全文获取路径: Springer  (合作)
影响因子:1.869 (2012)

  • bacteriocin 细菌素
  • optimization 最佳化
  • mathematical 数学的
  • algorithm 算法
  • production 生产
  • model 模型
  • approach 
  • Application 应用