Synthesis and pharmacological evaluation of 4-[2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propoxy]-4-azatricyclo[ 2,6 ]dec-8-ene-3,5-dione
作者: Jerzy KossakowskiAnna BielenicaMarta StrugaAnna E. Koziol
作者单位: 1Department of Medical Chemistry, The Medical University of Warsaw
2Faculty of Chemistry, Maria Curie-Sklodowska University
刊名: Medicinal Chemistry Research, 2008, Vol.17 (8), pp.507-514
来源数据库: Springer Journal
DOI: 10.1007/s00044-008-9094-3
关键词: Cyclic imide derivativeN-phenylpiperazine derivative5HT 1A and 5HT 2A receptor affinity
英文摘要: Abstract(#br)The synthesis and pharmacological activity of 4-[2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propoxy]-4-aza-tricyclo[ 2,6 ]dec-8-ene-3,5-dione is described. The structure of the compound was confirmed by elemental analysis, 1 H nuclear magnetic resonance (NMR), 13 C NMR, mass spectra, and X-ray crystallography. The compound exhibited significant affinity to both 5-HT 1A and 5-HT 2A receptors, similarly to aripiprazole, which is an atypical antipsychotic drug.
全文获取路径: Springer  (合作)
影响因子:1.612 (2012)

  • propoxy 丙氧基
  • phenyl 苯基
  • evaluation 评价