LDL - R Ava II and Nco I Polymorphisms: An Indirect Risk Factor for Coronary Heart Disease Among a Mendelian Population of Delhi, India
作者: Ekata SinhaGagandeep Kaur WaliaBudh Prakash GuptaPradeep Kumar GhoshKallur Nava Saraswathy
作者单位: 1Department of Anthropology, University of Delhi (North Campus)
2Department of Human Biology, Punjabi University
3Aggarwal Dharmarth Hospital
刊名: Biochemical Genetics, 2010, Vol.48 (9-10), pp.807-815
来源数据库: Springer Journal
DOI: 10.1007/s10528-010-9361-0
关键词: LDL - R polymorphismEndogamous populationLinkage disequilibriumCase–control association study
英文摘要: Abstract(#br) Ava II and Nco I polymorphisms in the low-density lipoprotein receptor ( LDL - R ) gene are reported to alter cholesterol levels. Although found to be highly polymorphic worldwide, these mutations have not been validated in any Indian population. This case–control association study was conducted in an endogamous business community of Delhi. Blood samples from 100 cases and 100 age- and sex-matched controls belonging to the same ethnic group were subjected to biochemical and molecular analyses. Medical history and anthropometric measurements were taken from all the enrolled subjects. Linkage disequilibrium between the two polymorphisms was found to be significant ( P = 0.0016). Significant variability was observed for the Ava II polymorphism among cases concerning waist–hip...
全文获取路径: Springer  (合作)
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影响因子:0.938 (2012)

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