Muscle-Specific RING Finger (MuRF) cDNAs in Atlantic Salmon ( Salmo salar ) and Their Role as Regulators of Muscle Protein Degradation
作者: Luca TacchiRalph BickerdikeChristopher J. SecombesSamuel A. M. Martin
作者单位: 1Institute of Biological and Environmental Sciences, University of Aberdeen
2BioMar Ltd
刊名: Marine Biotechnology, 2012, Vol.14 (1), pp.35-45
来源数据库: Springer Nature Journal
DOI: 10.1007/s10126-011-9385-4
关键词: Atlantic salmonProteasomeMuRF1MuRF2Protein degradationE3 ubiquitin ligase
原始语种摘要: Abstract(#br)The selection of proteins destined for degradation by the ubiquitin–proteasome pathway is coordinated by E3 ubiquitin ligases (E3Ub). One group of E3Ubs is described as muscle-specific RING finger (MuRF) molecules. In mammals, these proteins are believed to be central to targetting of muscle proteins for degradation during physiological perturbations such as starvation and inflammatory responses. In fish, the diversity of MuRF sequences is unexplored as is the expression of their mRNAs. In this study, three MuRF1 cDNAs, denoted as MuRF1a, MuRF1b, and MuRF1c, and a single MuRF2 were identified and characterized in Atlantic salmon. The MuRF1 sequences are highly conserved and encode predicted proteins of 349, 350, and 353 amino acids, whereas MuRF2 encodes a longer protein of...
全文获取路径: Springer Nature  (合作)
影响因子:2.739 (2012)

  • salar 干盐湖
  • Atlantic 在西洋的
  • Finger 指状夹