In Vivo toxicity assessment of gold nanoparticles in Drosophila melanogaster
作者: Pier Paolo PompaGiuseppe VecchioAntonio GaleoneVirgilio BrunettiStefania SabellaGabriele MaioranoAndrea FalquiGiovanni BertoniRoberto Cingolani
作者单位: 1Center for Bio-Molecular Nanotechnology
2Central Research Laboratories
刊名: Nano Research, 2011, Vol.4 (4), pp.405-413
来源数据库: Springer Journal
DOI: 10.1007/s12274-011-0095-z
关键词: Nanoparticlesnanotoxicologygoldin vivo studies
英文摘要: Abstract(#br) The growing use of nanomaterials in commercial goods and novel technologies is generating increasing questions about possible risks for human health and environment, due to the lack of an in-depth assessment of their potential toxicity. In this context, we investigated the effects of citrate-capped gold nanoparticles (AuNPs) on the model system Drosophila melanogaster upon ingestion. We observed a significant in vivo toxicity of AuNPs, which elicited clear adverse effects in treated organisms, such as a strong reduction of their life span and fertility, presence of DNA fragmentation, as well as a significant overexpression of the stress proteins. Transmission electron microscopy demonstrated the localization of the nanoparticles in tissues of Drosophila . The experimental...
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影响因子:7.392 (2012)

  • assessment 评价
  • toxicity 毒性