Mining for genotype-phenotype relations in Saccharomyces using partial least squares
作者: Tahir MehmoodHarald MartensSolve SæbøJonas WarringerLars Snipen
作者单位: 1Norwegian University of Life Sciences
2Centre of Integrative Genetics (CIGENE)
3University of Gothenburg
刊名: BMC Bioinformatics, 2011, Vol.12 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/1471-2105-12-318
英文摘要: Abstract(#br) Background(#br)Multivariate approaches are important due to their versatility and applications in many fields as it provides decisive advantages over univariate analysis in many ways. Genome wide association studies are rapidly emerging, but approaches in hand pay less attention to multivariate relation between genotype and phenotype. We introduce a methodology based on a BLAST approach for extracting information from genomic sequences and Soft- Thresholding Partial Least Squares (ST-PLS) for mapping genotype-phenotype relations.(#br) Results(#br)Applying this methodology to an extensive data set for the model yeast Saccharomyces cerevisiae , we found that the relationship between genotype-phenotype involves surprisingly few genes in the sense that an overwhelmingly large...
全文获取路径: PDF下载  Springer Nature  (合作)
影响因子:3.024 (2012)

  • partial 局部的
  • relations 性行为
  • least 最少的
  • phenotype 表型
  • genotype 属型