Serotonin transporter gene ( SLC6A4 ) polymorphisms are associated with response to fluoxetine in south Indian major depressive disorder patients
作者: Aarthi ManoharanDeepak Gopal ShewadeRavi Philip RajkumarSurendiran Adithan
作者单位: 1Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)
刊名: European Journal of Clinical Pharmacology, 2016, Vol.72 (10), pp.1215-1220
来源数据库: Springer Nature Journal
DOI: 10.1007/s00228-016-2099-9
关键词: SLC6A4FluoxetineResponseMajor depression
原始语种摘要: Abstract(#br) Purpose(#br)Up to 30–40 % of the major depressive disorder patients do not respond sufficiently to antidepressant treatment. Genetic variations in the serotonin transporter gene have been implicated in modulating treatment response to selective serotonin reuptake inhibitors, and this association is influenced by ethnicity. We investigated the influence of serotonin transporter gene variants 5-HTTLPR and rs25531 in Indian population on fluoxetine response.(#br) Methods(#br)One hundred and two major depressive disorder patients were started on fluoxetine treatment and after 6 weeks, classified as responders ( n = 56) and non-responders ( n = 46) using Hamilton depression rating scale and genotyped. Fisher’s exact test was used to compare genotype frequencies between responders...
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影响因子:2.741 (2012)

  • fluoxetine 氟西汀
  • depressive 降低的
  • disorder 无序
  • associated 相关的
  • transporter 运送机
  • major 知的
  • response 响应
  • Indian 印弟安星座
  • south 南方的