Inhibitory effects of Mycoepoxydiene on macrophage foam cell formation and atherosclerosis in ApoE-deficient mice
作者: Xiaochun XiaYang LiQiang SuZhengrong HuangYuemao ShenWeihua LiChundong Yu
作者单位: 1The First Affiliated Hospital of Xiamen University
2Xiamen University
3Shandong University
刊名: Cell & Bioscience, 2015, Vol.5 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s13578-015-0017-y
关键词: Mycoepoxydieneox-LDLMacrophageFoam cellAtherosclerosis
原始语种摘要: Abstract(#br) Background(#br)Mycoepoxydiene (MED) is a polyketide that can be isolated from a marine fungus and is associated with various activities, including antitumor and anti-inflammatory functions. However, its effects on atherosclerosis remain unknown. Macrophage-derived foam cells play crucial roles in the initiation and progression of atherosclerotic plaques. In this study, we investigated the effects of MED on oxidized low-density lipoprotein (ox-LDL)-induced macrophage foam cell formation and activation, and on high fat diet (HFD)-induced atherosclerosis in ApoE-deficient ( ApoE −/− ) mice.(#br) Results(#br)Our findings show that MED could significantly inhibit ox-LDL-induced macrophage foam cell formation and suppress the expression of lectin-like oxidized...
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影响因子:3 (2012)

  • macrophage 巨噬细胞
  • deficient 缺乏
  • formation 建造
  • effects 海员自身物品