Expression of Peroxisome Proliferator Activated Receptor-Gamma (PPAR-γ) in Human Non-small Cell Lung Carcinoma: Correlation with Clinicopathological Parameters, Proliferation and Apoptosis Related Molecules and Patients’ Survival
作者: Costantinos GiaginisEkaterini PolitiParaskevi AlexandrouJohn SfiniadakisGregory KouraklisStamatios Theocharis
作者单位: 1Department of Forensic Medicine and Toxicology, Medical School, University of Athens
2Department of Food Science and Nutrition, University of the Aegean
3Department of Pathology, Naval Hospital Athens
4Second Department of Propedeutic Surgery, Medical School, University of Athens
刊名: Pathology & Oncology Research, 2012, Vol.18 (4), pp.875-883
来源数据库: Springer Journal
DOI: 10.1007/s12253-012-9517-9
关键词: PPAR-γNon-small cell lung carcinomaImmunohistochemistryCell cycleCell proliferationApoptosis
英文摘要: Abstract(#br)Peroxisome proliferator-activated receptor-γ (PPAR-γ) has currently been considered as molecular target for the treatment of human metabolic disorders. PPAR-γ has also been implicated in the pathogenesis and progression of several types of cancer, being associated with cell differentiation, growth and apoptosis. The present study aimed to evaluate the clinical significance of PPAR-γ expression in non-small cell lung carcinoma (NSCLC). PPAR-γ protein expression was assessed immunohistochemically in tumoral samples of 67 NSCLC patients and was statistically analyzed in relation to clinicopathological parameters, proliferation and apoptosis related molecules and patients’ survival. Positive PPAR-γ expression was prominent in 30 (45 %) out of 67 NSCLC cases. PPAR-γ positivity was...
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影响因子:1.555 (2012)

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