Acylated ghrelin protects hippocampal neurons in pilocarpine-induced seizures of immature rats by inhibiting cell apoptosis
作者: Ruiyun ZhangGuanglu YangQingyi WangFeng GuoHua Wang
作者单位: 1Department of Pediatrics, Shengjing Hospital, China Medical University
2Department of Pediatrics, Hongqi Hospital, Mudanjiang Medical University
3Department of Orthopaedics, Hongqi Hospital, Mudanjiang Medical University
4Department of Pharmaceutical Toxicology, School of Pharmaceutical Science, China Medical University
刊名: Molecular Biology Reports, 2013, Vol.40 (1), pp.51-58
来源数据库: Springer Journal
DOI: 10.1007/s11033-012-1993-1
关键词: Acylated ghrelinApoptosisNeuroprotective effectEpilepsyHippocampusPilocarpine
英文摘要: Abstract(#br)Ghrelin has two major molecular forms, acylated ghrelin (AG) and unacylated ghrelin (UAG). Only AG to bind growth hormone secretagogue receptor 1a (GHSR-1a) has central endocrine activities. An antiapoptotic effect of AG in cortical neuronal cells has recently been reported. However, whether there is a neuroprotective effect of AG in hippocampal neurons of pilocarpine-induced seizures in rats, is still unknown. Therefore, in the present study, the underlying mechanism of AG on lithium-pilocarpine-induced excitotoxicity was examined in the hippocampus of rat. The results showed that AG inhibited pilocarpine-induced apoptosis. Exposure of rats to the receptor-specific antagonist D-Lys-3-GHRH-6 abolished the protective effects of AG against epilepsy. Administration of AG...
全文获取路径: Springer  (合作)
影响因子:2.506 (2012)

  • pilocarpine 匹鲁卡品
  • immature 未熟的
  • inhibiting 抑制
  • induced 感应的
  • apoptosis 细胞死