Molecular docking studies on analogues of quercetin with d -alanine: d -alanine ligase of Helicobacter pylori
作者: Salam Pradeep SinghRocktotpal KonwarhBolin Kumar KonwarNiranjan Karak
作者单位: 1Bioinformatics Infrastructure Facility, Department of Molecular Biology and Biotechnology, Tezpur University
2Advanced Polymer and Nanomaterial Laboratory, Department of Chemical Sciences, Tezpur University
刊名: Medicinal Chemistry Research, 2013, Vol.22 (5), pp.2139-2150
来源数据库: Springer Journal
DOI: 10.1007/s00044-012-0207-7
关键词: Antimicrobial agentAntibacterial activityFlavonoidsMolecular docking
英文摘要: Abstract(#br) Helicobacter pylori (Hp) is a human pathogen associated with myriad of diseases such as gastritis, peptic ulceration, piles and gastric cancer. The resistance of Hp against antimicrobial agents has increased just as that of other pathogens worldwide, thus emphasizing an urgent need for developing new antibacterial agents. The d -alanine: d -alanine ligase (Ddl, EC 6.3.2.4) has been considered as a putative antimicrobial drug target and a lot of inhibitor screening efforts have been made. Quercetin, a member of the flavonoids, characterized by a flavone nucleus composed of two benzene rings linked through a heterocyclic pyrone ring is reported to possess antibacterial activity against H. pylori Ddl (HpDdl) enzyme. In this milieu, we have performed molecular docking analysis...
全文获取路径: Springer  (合作)
分享到:
来源刊物:
影响因子:1.612 (2012)

×
关键词翻译
关键词翻译
  • alanine 丙氨酸
  • ligase 连接酶
  • Helicobacter 哈比特属
  • docking 靠泊
  • quercetin 槲皮苷