miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)
作者: Jaekwang KimFabienne C. FieselKrystal C. BelmonteRoman HudecWang-Xia WangChaeyoung KimPeter T. NelsonWolfdieter SpringerJungsu Kim
作者单位: 1Mayo Clinic College of Medicine
2University of Kentucky
3Neurobiology of Disease Program, Mayo Graduate School
刊名: Molecular Neurodegeneration, 2016, Vol.11 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s13024-016-0121-4
关键词: PINK1MitophagymiR-27amiR-27bParkinson’s disease
原始语种摘要: Abstract(#br) Background(#br)Loss-of-function mutations in PINK1 and PARKIN are the most common causes of autosomal recessive Parkinson’s disease (PD). PINK1 is a mitochondrial serine/threonine kinase that plays a critical role in mitophagy, a selective autophagic clearance of damaged mitochondria. Accumulating evidence suggests mitochondrial dysfunction is one of central mechanisms underlying PD pathogenesis. Therefore, identifying regulatory mechanisms of PINK1 expression may provide novel therapeutic opportunities for PD. Although post-translational stabilization of PINK1 upon mitochondrial damage has been extensively studied, little is known about the regulation mechanism of PINK1 at the transcriptional or translational levels.(#br) Results(#br)Here, we demonstrated that microRNA-27a...
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影响因子:4.007 (2012)

  • 控制 假定的
  • mitochondria 线粒体
  • induced 感应的
  • targeting 导向目标
  • damaged 残损
  • clearance 间隙
  • kinase 激酶
  • putative 假定的
  • regulate 假定的