Antigen-Specific IgG ameliorates allergic airway inflammation via Fcγ receptor IIB on dendritic cells
作者: Yumiko IshikawaKazuyuki KobayashiMasatsugu YamamotoKyosuke NakataTetsuya TakagawaYasuhiro FunadaYoshikazu KotaniHajime KarasuyamaMasaru YoshidaYoshihiro Nishimura
作者单位: 1Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
2Division of Metabolomics Research, Division of Gastroenterology, The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine
3Department of Immune Regulation, Tokyo Medical and Dental University Graduate School
刊名: Respiratory Research, 2011, Vol.12 (1), pp.1-10
来源数据库: Springer Journal
DOI: 10.1186/1465-9921-12-42
英文摘要: Abstract(#br) Background(#br)There have been few reports on the role of Fc receptors (FcRs) and immunoglobulin G (IgG) in asthma. The purpose of this study is to clarify the role of inhibitory FcRs and antigen presenting cells (APCs) in pathogenesis of asthma and to evaluate antigen-transporting and presenting capacity by APCs in the tracheobronchial mucosa.(#br) Methods(#br)In FcγRIIB deficient (KO) and C57BL/6 (WT) mice, the effects of intratracheal instillation of antigen-specific IgG were analysed using the model with sensitization and airborne challenge with ovalbumin (OVA). Thoracic lymph nodes instilled with fluorescein-conjugated OVA were analysed by fluorescence microscopy. Moreover, we analysed the CD11c + MHC class II + cells which intaken fluorescein-conjugated OVA in thoracic...
全文获取路径: Springer  (合作)
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影响因子:3.642 (2012)

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关键词翻译
关键词翻译
  • allergic 变应性的
  • airway 航路
  • inflammation 炎症
  • dendritic 师状的
  • receptor 接受体
  • cells 麻风细胞
  • IgG 免疫球蛋白 G