Urine kidney injury molecule-1: a potential non-invasive biomarker for patients with renal cell carcinoma
作者: Ping L. ZhangJoseph W. MashniVenkata S. SabbisettiCharles M. SchworerGeorge D. WilsonStacy C. WolforthKenneth M. KernenBrian D. SeifmanMitual B. AminTimothy J. GeddesFan LinJoseph V. BonventreJason M. Hafron
作者单位: 1Department of Anatomic Pathology, William Beaumont Hospital
2Department of Urology, William Beaumont Hospital
3Renal Division, Brigham and Women’s Hospital
4Weis Research Center and Lab Medicine, Geisinger Medical Center
5Beaumont Research Institute, William Beaumont Hospital
刊名: International Urology and Nephrology, 2014, Vol.46 (2), pp.379-388
来源数据库: Springer Nature Journal
DOI: 10.1007/s11255-013-0522-z
关键词: Kidney injury molecule-1Renal cell carcinomaRenal cystic lesions
英文摘要: Abstract(#br) Background(#br)KIM-1 staining is upregulated in proximal tubule-derived renal cell carcinoma (RCC) including clear renal cell carcinoma and papillary renal cell carcinoma, but not in chromophobe RCC (distal tubular tumor). This study was designed to prospectively examine urine KIM-1 level before and 1 month after removal of renal tumors.(#br) Patients and design(#br)A total of 19 patients were eventually enrolled in the study based on pre-operative imaging studies. Pre-operative and follow-up (1 month) urine KIM-1 levels were measured. The urine KIM-1 levels (uKIM-1) were then normalized to urine creatinine levels (uCr). Renal tumors were also stained for KIM-1 using immunohistochemical techniques.(#br) Results(#br)The KIM-1-negative staining group included 7 cases, and the...
全文获取路径: Springer Nature  (合作)
影响因子:1.325 (2012)

  • potential 
  • carcinoma 癌症
  • renal 肾的
  • invasive 侵入的
  • biomarker 生物标志化合物
  • molecule 分子
  • injury 损害
  • kidney 肾脏