Pharmacokinetics, Safety and Tolerability of Rotigotine Transdermal Patch in Healthy Japanese and Caucasian Subjects
作者: Willi CawelloSeong R. KimMarina BraunJan-Peer ElshoffJunji IkedaTomoo Funaki
作者单位: 1UCB Pharma
2Otsuka Pharmaceutical Co. Ltd.
刊名: Clinical Drug Investigation, 2014, Vol.34 (2), pp.95-105
来源数据库: Springer Journal
DOI: 10.1007/s40261-013-0150-5
英文摘要: Abstract(#br) Background and Objectives(#br)Rotigotine is a dopamine receptor agonist with activity across the D 1 through to D 5 receptors as well as select serotonergic and adrenergic sites; continuous transdermal delivery of rotigotine with replacement of the patch once daily maintains stable plasma concentrations over 24 h. Rotigotine is indicated for the treatment of early and advanced-stage Parkinson’s disease and moderate-to-severe idiopathic restless legs syndrome. The pharmacokinetics and pharmacodynamics of a drug may vary between subjects of different ethnic origin. This study evaluated the pharmacokinetics, safety, and tolerability of single-dose treatment with rotigotine transdermal patch in Japanese and Caucasian subjects.(#br) Methods(#br)In this open-label, parallel-group...
全文获取路径: Springer  (合作)
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影响因子:1.915 (2012)

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