Effect of CYP2C9 , VKORC1 , CYP4F2 and GGCX genetic variants on warfarin maintenance dose and explicating a new pharmacogenetic algorithm in South Indian population
作者: Dhakchinamoorthi Krishna KumarDeepak Gopal ShewadeMarie-Anne LoriotPhilippe BeauneJayaraman BalachanderB. V. Sai ChandranChandrasekaran Adithan
作者单位: 1Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER)
2University Paris Sorbonne Cité, INSERM UMRS 775
3Department of Biochemistry, Georges Pompidou European Hospital, Assistance Publique des Hôpitaux de Paris
4Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER)
5Department of Cardiothoracic and Vascular Surgery, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER)
刊名: European Journal of Clinical Pharmacology, 2014, Vol.70 (1), pp.47-56
来源数据库: Springer Nature Journal
DOI: 10.1007/s00228-013-1581-x
关键词: WarfarinGenotypePolymorphismsPharmacogenetic algorithm
原始语种摘要: Abstract(#br) Objective(#br)To determine the influence of genetic polymorphisms on warfarin maintenance dose and to explicate an algorithm using the pharmacogenetic and clinical factors to determine the maintenance and/or starting dose of warfarin in South Indian patients receiving warfarin therapy.(#br) Methods(#br)Patients receiving stabilized warfarin therapy ( n = 257) were included in the study. Single nucleotide polymorphisms (SNPs) of CYP2C9 (rs1799853 and rs1057910), VKORC1 (rs9923231, rs7196161, rs2884737, rs9934438, rs8050894, rs2359612 and rs7294), CYP4F2 (rs2108622) and GGCX (rs11676382) were genotyped by the quantitative real time-PCR method.(#br) Results(#br)The mean daily maintenance dose of warfarin was found to be 4.7 ± 2.1 mg/day. Patients with the CYP2C9 *1/*2, *1/*3...
全文获取路径: Springer Nature  (合作)
影响因子:2.741 (2012)

  • warfarin 杀鼠灵
  • maintenance 维持
  • population 母体
  • genetic 遗传的
  • Indian 印弟安星座
  • algorithm 算法