Near-Infrared Light-Sensitive Liposomes for the Enhanced Photothermal Tumor Treatment by the Combination with Chemotherapy
作者: Jian YouPeizun ZhangFuqiang HuYongzhong DuHong YuanJiang ZhuZuhua WangJialin ZhouChun Li
作者单位: 1College of Pharmaceutical Sciences, Zhejiang University
2Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
3Department of Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center
刊名: Pharmaceutical Research, 2014, Vol.31 (3), pp.554-565
来源数据库: Springer Journal
DOI: 10.1007/s11095-013-1180-7
关键词: controlled releaselight sensitive liposomesphotothermal effect
英文摘要: Abstract(#br) Purpose(#br)To develop a near-infrared (NIR) light-sensitive liposome, which contains hollow gold nanospheres (HAuNS) and doxorubicin (DOX), and evaluate their potential utility for enhancing antitumor activity and controlling drug release.(#br) Methods(#br)The liposomes (DOX&HAuNS-TSL) were designed based on a thermal sensitive liposome (TSL) formulation, and hydrophobically modified HAuNS were attached onto the membrane of the liposomes. The behavior of DOX release from the liposomes was investigated by the dialysis, diffusion in agarose gel and cellular uptake of the drug. The biodistribution of DOX&HAuNS-TSL was assessed by i.v. injection in tumor-bearing nude mice. Antitumor efficacy was evaluated both histologically using excised tissue and intuitively by measuring the...
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影响因子:4.742 (2012)

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