Clinical significance of histone deacetylase (HDAC)-1, HDAC-2, HDAC-4, and HDAC-6 expression in human malignant and benign thyroid lesions
作者: Constantinos GiaginisParaskevi AlexandrouIoanna DelladetsimaIoanna GiannopoulouEfstratios PatsourisStamatios Theocharis
作者单位: 1First Department of Pathology, Medical School, University of Athens
2Department of Food Science and Nutrition, University of the Aegean
刊名: Tumor Biology, 2014, Vol.35 (1), pp.61-71
来源数据库: Springer Journal
DOI: 10.1007/s13277-013-1007-5
关键词: Thyroid malignancyHistone deacetylasesClinicopathological parametersImmunohistochemistry
英文摘要: Abstract(#br)Histone deacetylases (HDACs) have been associated with human malignant tumor development and progression, and HDAC inhibitors are currently being explored as anticancer agents in clinical trials. The present study aimed to evaluate the clinical significance of HDAC-1, HDAC-2, HDAC-4, and HDAC-6 proteins' expression in human malignant and benign thyroid lesions. HDAC-1, HDAC-2, HDAC-4, and HDAC-6 proteins' expression was assessed immunohistochemically on paraffin-embedded thyroid tissues obtained from 74 patients with benign and malignant thyroid lesions. Enhanced HDAC-2 and HDAC-6 expression was significantly more frequently observed in malignant, compared to benign, thyroid lesions ( p = 0.0042 and p = 0.0069, respectively). Enhanced HDAC-2, HDAC-4, and HDAC-6 expression was...
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影响因子:2.518 (2012)

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关键词翻译
关键词翻译
  • deacetylase 脱乙酰基酶
  • benign 良性的
  • histone 组蛋白
  • malignant 恶性的
  • significance 显著性
  • expression 表示
  • human 人的
  • thyroid 甲状腺