Dipeptidyl Peptidase IV Inhibition Prevents the Formation and Promotes the Healing of Indomethacin-Induced Intestinal Ulcers in Rats
作者: Takuya InoueMasaaki HigashiyamaIzumi KajiSergiy RudenkyyKazuhide HiguchiPaul H. GuthEli EngelJonathan D. KaunitzYasutada Akiba
作者单位: 1Greater Los Angles Veterans Affairs Healthcare System
2Department of Medicine, University of California, Los Angeles
3Department of Biomathematics, University of California, Los Angeles
4Brentwood Biomedical Research Institute
5The Second Department of Internal Medicine, Osaka Medical College
6West Los Angeles VA Medical Center
刊名: Digestive Diseases and Sciences, 2014, Vol.59 (6), pp.1286-1295
来源数据库: Springer Journal
DOI: 10.1007/s10620-013-3001-6
关键词: Glucagon-like peptide-2NSAIDsTaste receptor
英文摘要: Abstract(#br) Backgrounds and Aims(#br)We studied the intestinotrophic hormone glucagon-like peptide-2 (GLP-2) as a possible therapy for non-steroidal anti-inflammatory drug (NSAID)-induced intestinal ulcers. Luminal nutrients release endogenous GLP-2 from enteroendocrine L cells. Since GLP-2 is degraded by dipeptidyl peptidase IV (DPPIV), we hypothesized that DPPIV inhibition combined with luminal administration of nutrients potentiates the effects of endogenous GLP-2 on intestinal injury.(#br) Methods(#br)Intestinal injury was induced by indomethacin (10 mg/kg, sc) in fed rats. The long-acting DPPIV inhibitor K579 was given intragastrically (ig) or intraperitoneally (ip) before or after indomethacin treatment. l -Alanine ( l -Ala) and inosine 5′-monophosphate (IMP) were co-administered...
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影响因子:2.26 (2012)

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