Bimonthly regimen of high-dose leucovorin, infusional 5-fluorouracil, docetaxel, and cisplatin (modified DCF) in advanced gastric adenocarcinoma
作者: Ilkay Tugba UnekTulay AkmanIlhan OztopOlcun Umit UnalTarik SalmanUgur Yilmaz
作者单位: 1Department of Internal Medicine, Division of Medical Oncology, Dokuz Eylul University School of Medicine
2Dokuz Eylul University Institute of Oncology
刊名: Gastric Cancer, 2013, Vol.16 (3), pp.428-434
来源数据库: Springer Nature Journal
DOI: 10.1007/s10120-012-0206-x
关键词: Advanced gastric cancerDocetaxelCisplatinLeucovorin5-Fluorouracil
英文摘要: Abstract(#br) Background(#br)The combination of docetaxel, cisplatin, and 5-fluorouracil (DCF) is an effective but highly toxic regimen for the treatment of advanced gastric cancer. To improve tolerability while maintaining the efficacy of the DCF regimen, we developed a modified DCF regimen including an infusional 5-fluorouracil administration according to the de Gramont regimen.(#br) Methods(#br)In this study, 70 patients with advanced gastric cancer were treated. Each 2-week cycle consisted of docetaxel (60 mg/m 2 ), cisplatin (50 mg/m 2 ), a 5-fluorouracil (400 mg/m 2 ) IV bolus, and 5-fluorouracil (2,400 mg/m 2 ) IV over 46 h plus leucovorin (400 mg/m 2 ) IV over 2 h.(#br) Results(#br)The median progression-free survival and overall survival were 9.0 months (95 % CI, 7.1–10.9) and...
全文获取路径: Springer Nature  (合作)
影响因子:3.989 (2012)

  • cisplatin 顺氯氨铂
  • adenocarcinoma 腺癌
  • leucovorin 甲酰四氢叶酸
  • gastric 胃的
  • fluorouracil 氟尿嘧啶
  • regimen 生活制度
  • advanced 先进的