Expression analysis of programmed death ligand 2 in tumors caused by the avian oncovirus Marek’s disease virus
作者: Ayumi Matsuyama-KatoShiro MurataMasayoshi IsezakiSarah TakasakiRika KanoSatoru KonnaiKazuhiko Ohashi
作者单位: 1Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
刊名: Archives of Virology, 2014, Vol.159 (8), pp.2123-2126
来源数据库: Springer Nature Journal
DOI: 10.1007/s00705-014-2021-7
关键词: Marek’s diseaseGallid herpesvirus 2Programmed death ligand 2Tumor
英文摘要: Abstract(#br)PD-L2 is a ligand of the immunoinhibitory receptor PD-1. Here, we report functional and expression analyses of PD-L2 in tumor lesions and spleens from chickens infected with gallid herpesvirus 2 (GaHV-2, Marek’s disease virus), which induces malignant lymphomas in chickens. We show that the expression of IFN-γ protein was decreased in PBMCs and splenocytes co-cultured with PD-L2-expressing cells and that the expression of PD-L2 mRNA was significantly higher in the spleens of infected chickens in the latent phase and in tumor lesions caused by GaHV-2. These results suggest that chicken PD-L2 has an immunoinhibitory function and is involved in the establishment of latency and tumor formation by GaHV-2.
全文获取路径: Springer Nature  (合作)
影响因子:2.03 (2012)

  • programmed 制订计划了的编制程序了的按程序工作的
  • avian 鸟的
  • analysis 分析
  • virus 病毒
  • ligand 配合体
  • disease 
  • death