Clinical significance of HuR expression in human malignancy
作者: Ioly Kotta-LoizouConstantinos GiaginisStamatios Theocharis
作者单位: 1Division of Cell and Molecular Biology, Imperial College London
2First Department of Pathology, Medical School, University of Athens
3Department of Food Science and Nutrition, University of the Aegean
刊名: Medical Oncology, 2014, Vol.31 (9), pp.1-19
来源数据库: Springer Journal
DOI: 10.1007/s12032-014-0161-y
关键词: HuRCancerPrognosisClinicopathological parametersCOX-2Therapeutic target
英文摘要: Abstract(#br)Hu-antigen R (HuR) is an RNA-binding protein that regulates the stability, translation, and nucleus-to-cytoplasm translocation of target mRNAs. The aim of the present review was to summarize and present the currently available information in the English literature on HuR expression in various human tumors, verifying its possible clinical significance. HuR function is directly linked to its subcellular localization. In normal cells, HuR is mostly localized in the nucleus, while in malignant cells, an increase in cytoplasmic HuR levels has been noted, in both cell lines and tissue samples. Moreover, in malignancy, elevated HuR expression levels and cytoplasmic immunohistochemical pattern have been correlated with advanced clinicopathological parameters and altered expression...
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来源刊物:
影响因子:2.147 (2012)

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关键词翻译
关键词翻译
  • malignancy 恶性
  • significance 显著性
  • expression 表示
  • human 人的