Life and death of female gametes during oogenesis and folliculogenesis
作者: Dmitri V. KryskoAraceli Diez-FraileGodelieve CrielAndrei A. SvistunovPeter VandenabeeleKatharina D’Herde
作者单位: 1Department for Molecular Biomedical Research, Molecular Signaling and Cell Death Unit, VIB
2Department of Molecular Biology, Ghent University
3Department of Human Anatomy, Embryology, Histology and Medical Physics, Ghent University
4Department of Pharmacology and Clinical Pharmacology, Saratov State Medical University
刊名: Apoptosis, 2008, Vol.13 (9), pp.1065-1087
来源数据库: Springer Journal
DOI: 10.1007/s10495-008-0238-1
关键词: Granulosa cellFollicular fluidFollicular atresiaApoptosisCaspasesPremature ovarian failureAutophagyNeo-oogenesisGap junctions
英文摘要: Abstract(#br)The vertebrate ovary is an extremely dynamic organ in which excessive or defective follicles are rapidly and effectively eliminated early in ontogeny and thereafter continuously throughout reproductive life. More than 99% of follicles disappear, primarily due to apoptosis of granulosa cells, and only a minute fraction of the surviving follicles successfully complete the path to ovulation. The balance between signals for cell death and survival determines the destiny of the follicles. An abnormally high rate of cell death followed by atresia can negatively affect fertility and eventually lead irreversibly to premature ovarian failure. In this review we provide a short overview of the role of programmed cell death in prenatal differentiation of the primordial germ cells and in...
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影响因子:3.949 (2012)

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关键词翻译
关键词翻译
  • oogenesis 卵子发生
  • during 在的期间
  • female 女性的
  • death