Clinical Significance of MCM-2 and MCM-5 Expression in Colon Cancer: Association with Clinicopathological Parameters and Tumor Proliferative Capacity
作者: Constantinos GiaginisMaria GeorgiadouKonstantina DimakopoulouGerasimos TsourouflisElisavet GatzidouGregorios KouraklisStamatios Theocharis
作者单位: 1Department of Forensic Medicine and Toxicology, Medical School, University of Athens
2Second Department of Propedeutic Surgery, Laikon Hospital, Medical School, University of Athens
刊名: Digestive Diseases and Sciences, 2009, Vol.54 (2), pp.282-291
来源数据库: Springer Journal
DOI: 10.1007/s10620-008-0305-z
关键词: MCM-2MCM-5Ki-67p53Cell proliferationClinicopathological parametersColon cancer
英文摘要: Abstract(#br)Minichromosome maintenance (MCM) proteins are essential components of DNA replication, being related to cell proliferation, and serve as useful markers for cancer screening, surveillance, and prognosis. Our aim was to examine the clinical significance of MCM-2 and MCM-5 protein expression in colon cancer and to evaluate the association with various clinicopathological characteristics and tumor proliferative capacity. Immunohistochemical expression of MCM-2 and MCM-5 was performed on paraffin-embedded malignant tissue sections obtained from 96 patients with colon cancer. MCM-2 and MCM-5 expression was correlated with different clinicopathological characteristics, proliferative capacity (Ki-67 labeling index), and p53 cell-cycle regulator expression. MCM-2 and Ki-67 expression...
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影响因子:2.26 (2012)

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  • Association 美国公共卫生协会
  • Cancer 巨蟹座