Synthesis, structure, DNA binding and cleavage activity of a new copper(II) complex of bispyridylpyrrolide
作者: Rui MinXiao-hui HuXiao-yi YiShou-chun Zhang
作者单位: 1Central South University
刊名: Journal of Central South University, 2015, Vol.22 (5), pp.1619-1625
来源数据库: Springer Nature Journal
DOI: 10.1007/s11771-015-2679-3
关键词: copper complexbispyridylpyrrolideDNA-bindingDNA cleavage
英文摘要: Abstract(#br)A copper-bispyridylpyrrolide complex [Cu(PDPH)Cl] (PDPH = 2,5-bis(2′-pyridyl)pyrrole) was synthesized and characterized. The complex crystallizes in the orthorhombic system with space group Pccn , a = 0.9016(3) nm, b = 1.0931(4) nm, c = 2.5319(8) nm, and V = 2.4951(15) nm3. The copper center is situated in a square planar geometry. The interaction of the copper(II) complex with calf thymus DNA (CT-DNA) was investigated by electronic absorption, circular dichroism (CD) and fluorescence spectra. It is proposed that the complex binds to CT-DNA through groove binding mode. Nuclease activity of the complex was also studied by gel electrophoresis method. The complex can efficiently cleave supercoiled pBR322 DNA in the presence of ascorbate...
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影响因子:0.434 (2012)

  • complex 超群
  • structure 构造
  • II Interactive Interface
  • copper 
  • activity 活度
  • binding 装订
  • cleavage 解理
  • DNA Deoxyribonucleic Acid