Insulin-like growth factor I is expressed in classical and nodular lymphocyte-predominant Hodgkin’s lymphoma tumour and microenvironmental cells
作者: Elisabeth EpplerEva JanasKarl LinkLukas WeidmannHelena BischofbergerMichael WengerMarianne TinguelyPeter SchramlHolger MochChristian Fellbaum
作者单位: 1University of Zurich
2University Hospital, Otto-von-Guericke-University
3University Hospital Zurich
4Kempf and Pfaltz, Histologische Diagnostik
5Institute of Pathology, Hegau-Bodensee Clinic
刊名: Cell and Tissue Research, 2015, Vol.359 (3), pp.841-851
来源数据库: Springer Journal
DOI: 10.1007/s00441-014-2052-0
关键词: IGF-IIGF-1RGrowth factorsHodgkin’s diseaseReed-Sternberg cellsLP cellsImmune cells
英文摘要: Abstract(#br)Hodgkin’s lymphoma (HL) is among the most frequent nodal lymphomas in the Western world and is classified into two disease entities: nodular lymphocyte-predominant Hodgkin’s lymphoma (NLPHL) and classical Hodgkin’s lymphoma (cHL, 95 % of all HL). HL lesions are characterised by a minority of clonal neoplastic cells, namely Hodgkin and Reed-Sternberg (HRS) cells and their variants in cHL and lymphocyte-predominant (LP) cells in NLPHL, both occurring within a microenvironment of, for example, reactive T and B cells, macrophages and granulocytes that are assumed to support the proliferation and maintenance of neoplastic cells through cytokines, chemokines and growth factors. Insulin-like growth factor I (IGF-I) is an important growth factor involved in proliferation,...
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影响因子:3.677 (2012)

  • lymphoma 淋巴瘤
  • nodular 结核状的
  • lymphocyte 淋巴细胞
  • tumour 肿瘤
  • expressed 榨出的
  • predominant 优势
  • classical 经典的
  • cells 麻风细胞
  • factor 因素
  • growth 生长