G-395A polymorphism in the promoter region of the KLOTHO gene associates with reduced cognitive impairment among the oldest old
作者: Qiukui HaoXiang DingLangli GaoMing YangBirong Dong
作者单位: 1Sichuan University
刊名: AGE, 2016, Vol.38 (1)
来源数据库: Springer Nature Journal
DOI: 10.1007/s11357-015-9869-7
关键词: KLOTHO geneCognitive impairmentSingle nucleotide polymorphism
原始语种摘要: Abstract(#br)This study aimed to examine the possible association between G-395A polymorphism in the promoter region of the KLOTHO gene and cognitive impairment among Chinese nonagenarians and centenarians. This study is a secondary analysis of the Project of Longevity and Aging in Dujiangyan (PLAD) study. Community-dwelling Chinese people aged 90 years or older were included. G-395A (rs1207568) genotyping in the promoter region of the KLOTHO gene was performed using the TaqMan allelic discrimination assay. Cognitive function was assessed with the mini-mental status examination (MMSE). A total of 706 participants (68.0 % female; mean age 93.5 ± 3.6 years) were included. The KLOTHO G-395A polymorphism genotype frequencies for the whole sample were 2.0 % AA, 30.3 % GA, and 67.7 % GG. The GG...
全文获取路径: PDF下载  Springer Nature  (合作)
分享到:
来源刊物:
影响因子:4.084 (2012)

×
关键词翻译
关键词翻译
  • region 地域
  • polymorphism 多晶形
  • promoter 催化剂
  • among 在当中
  • impairment 减损
  • reduced 减缩的
  • cognitive 修]认知[识