Effects of phenolic-rich extracts of Clinacanthus nutans on high fat and high cholesterol diet-induced insulin resistance
作者: Nadarajan SaregaMustapha Umar ImamNorhaizan Md EsaNorhasnida ZawawiMaznah Ismail
作者单位: 1Universiti Putra Malaysia
刊名: BMC Complementary and Alternative Medicine, 2016, Vol.16 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12906-016-1049-5
关键词: Clinacanthus noddingHigh fat and high cholesterol dietOGTTInsulin resistance
英文摘要: Abstract(#br) Background(#br) Clinacanthus nutans is used traditionally in many parts of Asia to improve well-being, but there are limited studies on its efficacy. We explored the potential use of C. nutans for prevention of high fat and high cholesterol diet-(HFHC-) induced insulin resistance in rats.(#br) Methods(#br)The leaf of C. nutans was extracted using water (AL extract) and methanol (AML extract), and the extracts were fed to rats alongside the HFHC diet for 7 weeks, and compared with simvastatin. Oral glucose tolerance test, and serum insulin, retinol binding protein 4 (RBP4), adiponectin and leptin were measured. Homeostatic model assessment of insulin resistance (HOMA-IR) was computed, while transcriptional regulation of hepatic insulin signaling genes was also assessed.(#br)...
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影响因子:2.082 (2012)

  • extracts 摘记
  • phenolic 苯酚的
  • cholesterol 胆甾醇
  • insulin 胰岛素
  • induced 感应的
  • resistance 抵抗