Expression pattern of class I histone deacetylases in vulvar intraepithelial neoplasia and vulvar cancer: a tissue microarray study
作者: Nicolas SamartzisPatrick ImeschKonstantin J DedesEleftherios P SamartzisAndré FedierDaniel FinkRosmarie CaduffMathias K Fehr
作者单位: 1University Hospital Zurich
2Hospital of Frauenfeld
刊名: BMC Cancer, 2011, Vol.11 (1)
来源数据库: Springer Journal
DOI: 10.1186/1471-2407-11-463
关键词: Histone deacetylaseepigeneticsvulvar intraepithelial neoplasiavulvar squamous cell cancertissue microarrayimmunohistochemistry
英文摘要: Abstract(#br) Background(#br)Epigenetic regulation is an important mechanism leading to cancer initiation and promotion. Histone acetylation by histone deacetylases (HDACs) represents an important part of it. The development of HDAC inhibitors has identified the utility of HDACs as a therapeutic target. Little is known about the epigenetic regulation of vulvar intraepithelial neoplasia (VIN) and vulvar squamous cell cancer (VSCC). In this study, the expression of class I HDACs (HDAC 1, 2 and 3) was compared in a series of VIN and VSCC tissues.(#br) Methods(#br)A tissue micro array (TMA) with specimens from 106 patients with high-grade VIN and 59 patients with vulvar cancer was constructed. The expression of HDACs 1, 2 and 3 were analyzed with immunohistochemistry (IHC). The nuclear...
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影响因子:3.333 (2012)

  • vulvar 阴户的
  • neoplasia 新生物形成
  • histone 组蛋白
  • pattern 模型
  • tissue 组织
  • class 
  • cancer 癌症
  • study 学习